GPCR regulation of secretion
نویسندگان
چکیده
منابع مشابه
Novel Structural Approaches to Study GPCR Regulation
BACKGROUND Upon natural agonist or pharmacological stimulation, G protein-coupled receptors (GPCRs) are subjected to posttranslational modifications, such as phosphorylation and ubiquitination. These posttranslational modifications allow protein-protein interactions that turn off and/or switch receptor signaling as well as trigger receptor internalization, recycling or degradation, among other ...
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Relaxin and estrogen reduced the resistance to dilatation of the mouse cervical canal. Relaxin was stored in, and secreted from , the ovaries of pregnant mice. The corpus luteum of gravid women just at delivery contained 25-50 GPU/g of relaxin, while the placenta, amniotic fluid and serum had no relaxin activity. Luteinizing hormone, luteotropic hormone and oxytocin effected elongation of the i...
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The exocrine pancreas secretes digestive enzymes, fluid, and bicarbonate in response to food ingestion. This is a critical digestive process that is regulated by neural reflexes, gastrointestinal hormones, and absorbed nutrients. Secretion is highly regulated by both stimulatory and inhibitory influences that coordinate the delivery of digestive enzymes with food emptying into the intestine to ...
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Address reprint requests to Dr. Heath. Receivedfor publication 3 August 1979 and in revisedform 10 September 1979. J. Clin. Invest. ©D The American Society for Clinical Investiga major importance in physiologic regulation of calcitonin secretion. The findings are consistent with the hypothesis that calcitonin functions to prevent excessive postprandial hypercalcemia.
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G protein-coupled receptors (GPCRs) mediate cellular responses to a variety of stimuli, but how specific responses are regulated has been elusive, as the types of GPCRs vastly outnumber the classes of G protein heterotrimers available to initiate downstream signaling. In our analysis of signaling proteins containing DEP domains ( approximately 90 residue sequence motifs first recognized in fly ...
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ژورنال
عنوان ژورنال: Pharmacology & Therapeutics
سال: 2018
ISSN: 0163-7258
DOI: 10.1016/j.pharmthera.2018.07.005